Altered balance between oxidants and antioxidants can trigger oxidative stress in human placenta and has important implications in the etiology of RPL
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Mitochondrial GSH transport (via SLC25A39) and the Nrf2-ARE regulatory pathway constitute key regulatory mechanisms at the tissue/cellular level, ensuring that GSH metabolism adapts to different physiological and pathological states
Hara T, Takeda TA, Takagishi T, Fukue K, Kambe T, Fukada T
Moreover, polyphenols often act on multiple pathways simultaneously, raising concerns of off-target effects that may not be fully elucidated in preclinical models
